PREVALENCE AND PREDICTORS OF STATIN PRESCRIPTION AMONG HIGH-RISK CARDIOVASCULAR PATIENTS IN NIGERIA
Authors & Affiliations
1.Francisca Olufunmilayo Inofomoh - Department of Medicine, Olabisi Onabanjo University and Olabisi Onabanjo University Teaching Hospital,Ogun State. 2.Yekeen Ayodele Ayoola - Department of Internal Medicine, Gombe State University, Gombe 3.Olumide Akinniyi Akinyele - Department of Medicine, Obafemi Awolowo University and Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife 4.Tajudin Adesegun Adetunji - Department of Medicine, Obafemi Awolowo University and Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife 5.Oladimeji Adedeji Junaid - Department of Internal Medicine, University of Medical Sciences, Ondo, Ondo State. 6.Tolulope Taiwo Shogade - Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State 7.Umar Faruk Abdullahi - Department of Medicine, Aminu Kano Teaching Hospital, Kano 8.Sebastine Oseghae Oiwoh - Department of Internal Medicine, Irrua Specialist Teaching Hospital, Irrua 9. Yusuf Idris Abiola - Federal Teaching Hospital Lafia, Nasarawa State 10. Yakubu Lawal - Department of Internal Medicine, University of Abuja, Abuja 11.Akinyele Taofiq Akinlade - Department of Medicine, General Hospital Lagos, Odan and Eko University of Medicine and Health Sciences, Lagos 12.Opeyemi Olalekan Oni - Department of Medicine, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso 13.Adenike Christianah Enikuomehin - Department of Medicine, University of Medical Sciences, Ondo State 14.Stella Chinyelu Alagbe - Department of Internal Medicine, General Hospital, Lagos and Eko University of Medicine and Health Sciences, Lagos 15.Dapo Sunday Oyedepo - Department of Internal Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara 16.Tijani Idris Ahmad Oseni - Department of Family Medicine, Edo State University Iyamho, Auchi, Edo 17.Oladimeji Adebayo - Institute of Cardiovascular Diseases, University of Ibadan, Ibadan 18.Ahidiyu Anaryu Mamza - Department of Internal Medicine, University of Maiduguri Teaching Hospital, Maiduguri, Borno 19.Oluseyi Ademola Adejumo - Department of Internal Medicine, University of Medical Sciences, Ondo, Ondo State, Nigeria 20.Adebimpe Olukemi Yusuf - Department of Medicine, Osun State University/UNIOSUN Teaching Hospital, Osogbo 21.Emmanuel Ovundah Nyeche – Department of Internal Medicine, Rivers State University, Port-Harcourt. 22.Joel Olufunminiyi Akande – Department of Chemical Pathology, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Oyo. 23.Atinuke Oluwabukola Kalada Richard - Department of Internal Medicine, General Hospital, Lagos and Eko University of Medicine and Health Sciences, Lagos 24.Oluwatosin Ruth Ilori - Department of Community Medicine, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Oyo 25.Bolade Folasade Dele-Ojo – Department of Internal Medicine, Ekiti State University Teaching Hospital, Ekiti. 26.Osahon Otaigbe - Department of Community Medicine, Irrua Specialist Teaching Hospital, Irrua 27.Damilola Adeyinka Akinfaderin – Department Internal Medicine, Federal University of Technology Akure Teaching Hospital, Ondo. 28.Adeseye Abiodun Akintunde - Department of Medicine, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Oyo
📖 Abstract Content
Dyslipidemia is a growing public health concern in Nigeria, with documented gaps in clinician knowledge, prescribing practice, and lipid disorder management. This study determined the prevalence of statin use and its clinical and sociodemographic predictors among high-risk cardiovascular patients in Nigeria.
This national cross-sectional study, conducted by Nigeria Clinical Lipid Research (NiCLiR) Network across selected tertiary and secondary health institutions in Nigeria over 10 months, enrolled adults aged ≥18 years with at least one high-risk condition per the 2018 ACC/AHA Primary Prevention Guideline. Statin prescription was defined as documented current use at data collection. Predictors were identified via multivariable logistic regression (p<0.05) in SPSS 28, adjusting for age, sex, region, hypertension, diabetes, stroke, peripheral vascular disease (PVD), chronic kidney disease, and left ventricular hypertrophy (LVH, diagnosed by ECG voltage criteria). Ethical approval was obtained from centres.
Of 1,470 high-risk participants, only 539 (36.7%) were prescribed statins. Prescription rates varied markedly by region, highest in the Southwest (321/722, 44.5%) and lowest in the North-East (27/231, 11.7%). Mean age and sex distribution did not differ significantly between groups (59.3±12.4 vs. 58.7±15.6 years; males/females 243/296 vs. 427/504, p>0.05). Statin prescription was significantly lower with LVH (96/251, p=0.002) and PVD (26/50, p=0.043).
Statin prescription was low among high-risk cardiovascular patients in Nigeria, with marked regional variation, highlighting an evidence-practice gap. Strategies to improve guideline-based prescription and equitable access to affordable statins are needed.
