Long-term outcome of peripartum cardiomyopathy at the university college hospital Ibadan
Authors & Affiliations
Anuoluwapo Makinde123*, Olanike Orimolade1,2,3, Joshua Akinyemi4, Chidinma Ogah3 , Ifunanya Nebo3, Abdulhammed Babatunde3 Omokorede Ademowo-Olusanya2,3,5, Akinyemi Aje1, , Oladimeji Adebayo2,5, Adeola Abdul-salam6,7, Gbolahan Obajimi6,7, Bukola Adesina6,7, Christopher Aimakhu6,7, Abiodun Adeoye1,2, Adewole Adebiyi 1,2 , Olulola Oladapo1,2 , Okechukwu Ogah1,2,3 Institutional affiliations 1Cardiology Unit, Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria 2Cardiology Unit, Department of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria 3Cardiomyopathies, Heart Failure and Atrial Fibrillation Research, Cardiology Unit, Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria 4Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria 5Institute of Cardiovascular Diseases, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria 6Department of Obstetrics & Gynaecology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria. 7Department of Obstetrics & Gynaecology, University College Hospital, Ibadan, Oyo State, Nigeria * Presenter Correspondence: Professor Okechukwu S Ogah, Cardiology Unit, Department of Medicine, University College Hospital Ibadan, PMB 5116, Ibadan, Nigeria
📖 Abstract Content
Background Peripartum cardiomyopathy (PPCM) is an important cause of maternal mortality and morbidity. There is limited data on outcomes and prognostic markers in patients receiving contemporary evidence-based therapy, particularly in southern Nigeria. The objective is to report the outcomes of PPCM in our setting. Methods We conducted a single-centre cohort study of 74 PPCM patients managed at the University College Hospital, Ibadan. The women were followed for a median of 16 months (range 1- 99 months). The primary endpoint was all-cause mortality. Results Seventy-four (74) patients with PPCM were seen between January 1, 2009, and December 31, 2022. The mean age of the women was 30.5 ± 6.9 years (range: 18-46 years). The mean BMI was 23.9 ± 3.8 Kg/m2 while the mean gestational age was 38.9 ± 2.4 weeks. Eighteen (24.3%) women were readmitted at least once, while 21 (28.4%) died during the follow-up period. The presence of these factors was significantly associated with higher rates of all-cause mortality: lower body mass index (p=0.017), lower systolic and diastolic blood pressures (p=0.003 and 0.020, respectively), and larger LV internal diameter in diastole (p=0.014). Conclusions This study identified factors associated with poorer outcomes in our cohort. The presence of pregnancy-induced hypertension appears to be associated with better outcomes
