PERIPARTUM CARDIOMYOPATHY IN NIGERIA (PEACE) REGISTRY

Peripartum Cardiomyopathy in Nigeria Registry is a longitudinal study that was carried out in 22 centres spread across Nigeria, between June 2017 and March 2019. Cardiologists in Nigeria were invited to participate as investigators through the email platform and conferences of the Nigerian Cardiac Society.

The primary objective of this study was to determine the burden, ventricular remodelling and survival of PPCM in Nigerian tertiary health centres. In the sub-studies, we aimed to determine the relationship between selenium deficiency, oxidative stress and PPCM, the impact of sodium selenite supplementation on left ventricular reverse remodelling, change in New York Heart Association functional class and survival in PPCM, and the prevalence of selenium deficiency and its relationship with cardiac function in apparently healthy pregnant women. The study results have been presented in various national and international scientific congresses including those of Nigerian Cardiac Society, American College of Cardiology, European Society of Cardiology, American Heart Association, Pan African Society of Cardiology, South African Heart Association and International Congress on Cardiac Problems in Pregnancy.

The study protocol and main results have been published in reputable peer-reviewed scientific journals:

1. Sa’idu H, Balarabe SA, Ishaq NA, Adamu UG, Mohammed IY, Oboirien I, Umuerri EM, Mankwe AC, Shidali VY, Njoku P, Dodiyi-Manuel S, Olunuga T, Josephs V, Mbakwem AC, Okolie H, Talle MA, Isa MS, Adebayo RA, Tukur J, Isezuo SA, Umar H, Shehu MN, Ogah OS, Karaye KM; PEACE Registry Investigators. Influence of systolic blood pressure on outcomes in Nigerians with peripartum cardiomyopathy. Niger J Clin Pract 2022; 25(12): 1963-1968.
2. Saidu H, Mohammed IY, Ishaq NA, Balarabe SA, Tukur J, Adedeji TA, Makinde ON, Adebayo RA, Umar H, Isezuo SA, Karaye KM. Impact of Parity on Cardiac Structure and Function in Apparently Healthy Pregnant Nigerian Women. West Afr J Med 2022; 39(10): 1057-1061.
3. Karaye KM. Overview of Primary Hypertension: A Clarion Call. West Afr J Med 2022; 39(6): 555-556.
4. Karaye KM, Ishaq NA, Sai’du H, Balarabe SA, Ahmed BG, Adamu UG, Mohammed IY, Oboirien I, Umuerri EM, Mankwe AC, Shidali VY, Dodiyi-Manuel S, Njoku P, Olunuga T, Josephs V, Mbakwem AC, Ogah OS, Tukur J, Okeahialam B, Stewart S, Henein M, Sliwa K; Peripartum Cardiomyopathy in Nigeria (PEACE) Registry Investigators. Disparities in clinical features and outcomes of peripartum cardiomyopathy in high versus low prevalent regions in Nigeria. ESC Heart Fail. 2021; 8(4): 3257-3267. doi: 10.1002/ehf2.13463.
5. Kamilu M Karaye. Learning from the peripartum cardiomyopathy in Nigeria (PEACE) registry: A multisite, contemporary PPCM registry in Nigeria. In Karen Sliwa, Editor. Peripartum Cardiomyopathy: from Pathophysiology to Management. London, San Diego, Cambridge (MA), Oxford: Elsevier Inc. 2021; 145-155.
6. Kamilu M Karaye, Hadiza Sa’idu, Sulaiman A Balarabe, Naser A Ishaq, Umar G Adamu, Idris Y Mohammed, Isa Oboirien, Ejiroghene M Umuerri, Abaram C Mankwe, Vincent Y Shidali, Paschal Njoku, Sotonye Dodiyi-Manuel, Taiwo Olunuga, Veronica Josephs, Amam C Mbakwem, Henry Okolie, Mohammed A Talle, Muhammad S Isa, Okechukwu S Ogah, Simon Stewart; on behalf of PEACE Registry Investigators. Clinical features and outcomes of Peripartum Cardiomyopathy in Nigeria. J Am Coll Cardiol 2020: 76(20): 2352-2364
7. Kamilu M Karaye, Hadiza Sa’idu; Suleiman A Balarabe; Naser A Ishaq; Bushra Sanni; Haruna Abubakar; Baba Lawan Mohammed; Tijjani Abdulsalam; Jamilu Tukur; Idris Y Mohammed. Selenium supplementation in patients with peripartum cardiomyopathy: a proof-of-concept trial. BMC Cardiovasc Disord 2020; 20: 457.
8. Kamilu M Karaye, Idris Y Mohammed, Hadiza Sa’idu, Naser A Ishaq, Suleiman A Balarabe, Jamilu Tukur, Tewogbade A Adedeji, Olufemiwa N Makinde, Rasaaq A Adebayo, on behalf of PEACE Registry Investigators. Prevalence of left ventricular dysfunction and relationship with serum selenium in apparently healthy pregnant women: results from the PEACE Registry. International Cardiovascular Forum Journal 2020; 20: 27-31.DOI : 10.17987/icfj.v20i0.687.
9. Karaye KM, Ishaq NA, Sa’idu H, Balarabe SA, Talle MA, Isa MS, Adamu UG, Umar H, Okolie HI, Shehu MN, Mohammed IY, Sanni B, Ogah OS, Oboirien I, Umuerri EM, Mankwe AC, Shidali VY, Njoku P, Dodiyi-Manuel S, Shogade TT, Olunuga T, Ojji D, Josephs V, Mbakwem AC, Tukur J, Isezuo SA; on behalf of PEACE Registry Investigators. Incidence, clinical characteristics, and risk factors of peripartum cardiomyopathy in Nigeria: results from the peripartum cardiomyopathy in Nigeria Registry. ESC Heart Fail 2020, DOI: 10.1002/ ehf2.12562
10. Karaye KM, Mohammed IY, Ogah OS and Basil N Okeahialam BN. Rationale and Design for the Peripartum Cardiomyopathy in Nigeria (PEACE) Registry. International Cardiovascular Forum Journal 2017; 12: 12-17. DOI: 10.17987/icfj.v12i0.462